ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

JENNISON ASSOCIATES LLC's Holding History (CIK: 0000053417)

Note: Option positions (PUT/CALL) are excluded.

Q4 2014
Shares 1,725,800 Value ($000) $106,551 Avg Close — Range —
Q3 2014
Shares 1,747,004 Value ($000) $67,836 Avg Close — Range —
Q2 2014
Shares 1,744,822 Value ($000) $60,109 Avg Close — Range —
Q1 2014
Shares 1,915,544 Value ($000) $82,771 Avg Close — Range —
Q4 2013
Shares 1,907,383 Value ($000) $75,990 Avg Close — Range —
Q3 2013
Shares 1,913,093 Value ($000) $71,818 Avg Close — Range —
Q2 2013
Shares 2,245,501 Value ($000) $60,337 Avg Close — Range —