ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

WELLS FARGO & COMPANY/MN's Holding History (CIK: 0000072971)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 533,096 Value ($000) $21,547 Avg Close — Range —
Q2 2015
Shares 553,328 Value ($000) $31,837 Avg Close — Range —
Q1 2015
Shares 578,705 Value ($000) $36,847 Avg Close — Range —
Q4 2014
Shares 596,730 Value ($000) $36,842 Avg Close — Range —
Q3 2014
Shares 553,537 Value ($000) $21,494 Avg Close — Range —
Q2 2014
Shares 544,551 Value ($000) $18,761 Avg Close — Range —
Q1 2014
Shares 637,862 Value ($000) $27,563 Avg Close — Range —
Q4 2013
Shares 774,400 Value ($000) $30,852 Avg Close — Range —
Q3 2013
Shares 782,140 Value ($000) $29,361 Avg Close — Range —
Q2 2013
Shares 1,217,045 Value ($000) $32,702 Avg Close — Range —