ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

PRICE T ROWE ASSOCIATES INC /MD/'s Holding History (CIK: 0000080255)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 1,677,543 Value ($000) $67,806 Avg Close — Range —
Q2 2015
Shares 1,649,805 Value ($000) $94,946 Avg Close — Range —
Q1 2015
Shares 1,489,258 Value ($000) $94,821 Avg Close — Range —
Q4 2014
Shares 2,678,378 Value ($000) $165,363 Avg Close — Range —
Q3 2014
Shares 2,754,750 Value ($000) $106,967 Avg Close — Range —
Q2 2014
Shares 2,766,278 Value ($000) $95,298 Avg Close — Range —
Q1 2014
Shares 3,229,257 Value ($000) $139,536 Avg Close — Range —
Q4 2013
Shares 3,349,415 Value ($000) $133,441 Avg Close — Range —
Q3 2013
Shares 3,413,045 Value ($000) $128,126 Avg Close — Range —
Q2 2013
Shares 3,835,755 Value ($000) $103,067 Avg Close — Range —