ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

STATE STREET CORP's Holding History (CIK: 0000093751)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 2,498,826 Value ($000) $100,996 Avg Close — Range —
Q2 2015
Shares 2,500,831 Value ($000) $143,929 Avg Close — Range —
Q1 2015
Shares 3,170,831 Value ($000) $201,885 Avg Close — Range —
Q4 2014
Shares 2,580,447 Value ($000) $159,317 Avg Close — Range —
Q3 2014
Shares 2,676,552 Value ($000) $103,933 Avg Close — Range —
Q2 2014
Shares 2,407,618 Value ($000) $82,941 Avg Close — Range —
Q1 2014
Shares 2,407,833 Value ($000) $104,042 Avg Close — Range —
Q4 2013
Shares 2,394,277 Value ($000) $95,394 Avg Close — Range —
Q3 2013
Shares 2,646,261 Value ($000) $99,345 Avg Close — Range —
Q2 2013
Shares 2,710,419 Value ($000) $72,830 Avg Close — Range —