ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

BARCLAYS PLC's Holding History (CIK: 0000312069)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 98,761 Value ($000) $3,952 Avg Close — Range —
Q2 2015
Shares 80,941 Value ($000) $4,616 Avg Close — Range —
Q1 2015
Shares 102,939 Value ($000) $6,486 Avg Close — Range —
Q4 2014
Shares 80,674 Value ($000) $4,921 Avg Close — Range —
Q3 2014
Shares 113,952 Value ($000) $4,330 Avg Close — Range —
Q2 2014
Shares 179,457 Value ($000) $6,102 Avg Close — Range —
Q1 2014
Shares 97,932 Value ($000) $4,210 Avg Close — Range —
Q4 2013
Shares 94,941 Value ($000) $3,703 Avg Close — Range —
Q3 2013
Shares 56,072 Value ($000) $2,075 Avg Close — Range —
Q2 2013
Shares 34,672 Value ($000) $931 Avg Close — Range —