ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

GLENMEDE TRUST CO NA's Holding History (CIK: 0000314949)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 110 Value ($000) $4 Avg Close — Range —
Q2 2015
Shares 85 Value ($000) $4 Avg Close — Range —
Q1 2015
Shares 3,685 Value ($000) $234 Avg Close — Range —
Q4 2014
Shares 4,085 Value ($000) $251 Avg Close — Range —
Q3 2014
Shares 4,085 Value ($000) $158 Avg Close — Range —
Q2 2014
Shares 7,708 Value ($000) $265 Avg Close — Range —
Q1 2014
Shares 3,608 Value ($000) $155 Avg Close — Range —
Q4 2013
Shares 3,208 Value ($000) $127 Avg Close — Range —
Q3 2013
Shares 2,800 Value ($000) $105 Avg Close — Range —
Q2 2013
Shares 2,860 Value ($000) $76 Avg Close — Range —