ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

FMR LLC's Holding History (CIK: 0000315066)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 17,687,647 Value ($000) $714,935 Avg Close — Range —
Q2 2015
Shares 17,650,302 Value ($000) $1,015,775 Avg Close — Range —
Q1 2015
Shares 17,546,050 Value ($000) $1,117,157 Avg Close — Range —
Q4 2014
Shares 17,531,733 Value ($000) $1,082,409 Avg Close — Range —
Q3 2014
Shares 17,549,733 Value ($000) $681,456 Avg Close — Range —
Q2 2014
Shares 17,549,733 Value ($000) $604,588 Avg Close — Range —
Q1 2014
Shares 17,549,733 Value ($000) $758,324 Avg Close — Range —
Q4 2013
Shares 16,957,719 Value ($000) $675,595 Avg Close — Range —
Q3 2013
Shares 16,987,719 Value ($000) $637,719 Avg Close — Range —
Q2 2013
Shares 16,222,264 Value ($000) $435,892 Avg Close — Range —