ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO's Holding History (CIK: 0000315297)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 29,029 Value ($000) $1,173 Avg Close — Range —
Q2 2015
Shares 29,070 Value ($000) $1,673 Avg Close — Range —
Q1 2015
Shares 26,688 Value ($000) $1,699 Avg Close — Range —
Q4 2014
Shares 26,688 Value ($000) $1,648 Avg Close — Range —
Q3 2014
Shares 30,416 Value ($000) $1,181 Avg Close — Range —
Q2 2014
Shares 33,004 Value ($000) $1,137 Avg Close — Range —
Q1 2014
Shares 33,004 Value ($000) $1,426 Avg Close — Range —
Q4 2013
Shares 33,004 Value ($000) $1,315 Avg Close — Range —
Q3 2013
Shares 33,004 Value ($000) $1,239 Avg Close — Range —
Q2 2013
Shares 33,004 Value ($000) $887 Avg Close — Range —