ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

FIL Ltd's Holding History (CIK: 0000318989)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 36,640 Value ($000) $1,481 Avg Close — Range —
Q2 2015
Shares 73,627 Value ($000) $4,238 Avg Close — Range —
Q1 2015
Shares 213,882 Value ($000) $13,617 Avg Close — Range —
Q4 2014
Shares 276,156 Value ($000) $17,050 Avg Close — Range —