ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

DIMENSIONAL FUND ADVISORS LP's Holding History (CIK: 0000354204)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 103,922 Value ($000) $4,197 Avg Close — Range —
Q2 2015
Shares 112,805 Value ($000) $6,491 Avg Close — Range —
Q1 2015
Shares 115,549 Value ($000) $7,357 Avg Close — Range —
Q4 2014
Shares 114,803 Value ($000) $7,088 Avg Close — Range —
Q3 2014
Shares 78,472 Value ($000) $3,050 Avg Close — Range —
Q2 2014
Shares 101,654 Value ($000) $3,504 Avg Close — Range —
Q1 2014
Shares 262,317 Value ($000) $11,332 Avg Close — Range —
Q4 2013
Shares 261,717 Value ($000) $10,427 Avg Close — Range —
Q3 2013
Shares 263,563 Value ($000) $9,895 Avg Close — Range —
Q2 2013
Shares 263,021 Value ($000) $7,068 Avg Close — Range —