ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Metropolitan Life Insurance Co/NY's Holding History (CIK: 0000728618)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 8,733 Value ($000) $353 Avg Close — Range —
Q2 2015
Shares 8,733 Value ($000) $503 Avg Close — Range —
Q1 2015
Shares 89,821 Value ($000) $5,719 Avg Close — Range —
Q4 2014
Shares 89,933 Value ($000) $5,552 Avg Close — Range —
Q3 2014
Shares 89,326 Value ($000) $3,469 Avg Close — Range —
Q2 2014
Shares 89,326 Value ($000) $3,077 Avg Close — Range —
Q1 2014
Shares 89,326 Value ($000) $3,860 Avg Close — Range —
Q4 2013
Shares 89,507 Value ($000) $3,566 Avg Close — Range —
Q3 2013
Shares 87,965 Value ($000) $3,302 Avg Close — Range —
Q2 2013
Shares 91,483 Value ($000) $2,458 Avg Close — Range —