ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

PINNACLE ASSOCIATES LTD's Holding History (CIK: 0000743127)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 1,778,325 Value ($000) $71,880 Avg Close — Range —
Q2 2015
Shares 1,828,878 Value ($000) $105,252 Avg Close — Range —
Q1 2015
Shares 1,889,017 Value ($000) $120,274 Avg Close — Range —
Q4 2014
Shares 1,917,838 Value ($000) $118,407 Avg Close — Range —
Q3 2014
Shares 1,845,727 Value ($000) $71,670 Avg Close — Range —
Q2 2014
Shares 1,914,942 Value ($000) $65,970 Avg Close — Range —
Q1 2014
Shares 1,940,664 Value ($000) $83,856 Avg Close — Range —
Q4 2013
Shares 2,016,369 Value ($000) $80,332 Avg Close — Range —
Q3 2013
Shares 2,064,760 Value ($000) $77,511 Avg Close — Range —
Q2 2013
Shares 2,119,363 Value ($000) $56,947 Avg Close — Range —