ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

AMERICAN CENTURY COMPANIES INC's Holding History (CIK: 0000748054)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 507,415 Value ($000) $20,510 Avg Close — Range —
Q2 2015
Shares 478,307 Value ($000) $27,527 Avg Close — Range —
Q1 2015
Shares 494,383 Value ($000) $31,477 Avg Close — Range —
Q4 2014
Shares 500,466 Value ($000) $30,899 Avg Close — Range —
Q3 2014
Shares 463,837 Value ($000) $18,011 Avg Close — Range —
Q2 2014
Shares 533,616 Value ($000) $18,383 Avg Close — Range —
Q1 2014
Shares 1,120,391 Value ($000) $48,412 Avg Close — Range —
Q4 2013
Shares 127,220 Value ($000) $5,068 Avg Close — Range —
Q3 2013
Shares 79,792 Value ($000) $2,995 Avg Close — Range —
Q2 2013
Shares 93,980 Value ($000) $2,525 Avg Close — Range —