ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

TEACHER RETIREMENT SYSTEM OF TEXAS's Holding History (CIK: 0000796848)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 6,410 Value ($000) $259 Avg Close — Range —
Q2 2015
Shares 4,688 Value ($000) $270 Avg Close — Range —
Q1 2015
Shares 3,580 Value ($000) $228 Avg Close — Range —
Q4 2014
Shares 3,566 Value ($000) $220 Avg Close — Range —
Q3 2014
Shares 4,033 Value ($000) $157 Avg Close — Range —
Q2 2014
Shares 4,402 Value ($000) $152 Avg Close — Range —
Q1 2014
Shares 4,590 Value ($000) $198 Avg Close — Range —
Q4 2013
Shares 4,304 Value ($000) $171 Avg Close — Range —
Q3 2013
Shares 13,278 Value ($000) $498 Avg Close — Range —
Q2 2013
Shares 7,606 Value ($000) $204 Avg Close — Range —