ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

NEW YORK STATE COMMON RETIREMENT FUND's Holding History (CIK: 0000810265)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 454,531 Value ($000) $18,372 Avg Close — Range —
Q2 2015
Shares 374,552 Value ($000) $21,555 Avg Close — Range —
Q1 2015
Shares 161,544 Value ($000) $10,286 Avg Close — Range —
Q4 2014
Shares 239,887 Value ($000) $14,811 Avg Close — Range —
Q3 2014
Shares 326,148 Value ($000) $12,664 Avg Close — Range —
Q2 2014
Shares 313,733 Value ($000) $10,808 Avg Close — Range —
Q1 2014
Shares 255,694 Value ($000) $11,049 Avg Close — Range —
Q4 2013
Shares 303,492 Value ($000) $12,091 Avg Close — Range —
Q3 2013
Shares 178,600 Value ($000) $6,705 Avg Close — Range —