ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

COMMERZBANK AKTIENGESELLSCHAFT /FI's Holding History (CIK: 0000852933)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 9,259 Value ($000) $374 Avg Close — Range —
Q2 2015
Shares 14,160 Value ($000) $815 Avg Close — Range —
Q1 2015
Shares 12,312 Value ($000) $784 Avg Close — Range —
Q3 2014
Shares 5,254 Value ($000) $204 Avg Close — Range —