ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

STATE OF WISCONSIN INVESTMENT BOARD's Holding History (CIK: 0000854157)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 89,310 Value ($000) $3,610 Avg Close — Range —
Q2 2015
Shares 91,900 Value ($000) $5,289 Avg Close — Range —
Q2 2014
Shares 130,000 Value ($000) $4,479 Avg Close — Range —