ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

VAN ECK ASSOCIATES CORP's Holding History (CIK: 0000869178)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 265,194 Value ($000) $10,719 Avg Close — Range —
Q2 2015
Shares 297,615 Value ($000) $17,128 Avg Close — Range —
Q1 2015
Shares 243,365 Value ($000) $15,495 Avg Close — Range —
Q4 2014
Shares 246,868 Value ($000) $15,242 Avg Close — Range —
Q3 2014
Shares 217,806 Value ($000) $8,457 Avg Close — Range —
Q2 2014
Shares 221,345 Value ($000) $7,625 Avg Close — Range —
Q1 2014
Shares 502,288 Value ($000) $21,704 Avg Close — Range —
Q4 2013
Shares 312,108 Value ($000) $12,434 Avg Close — Range —
Q3 2013
Shares 273,413 Value ($000) $10,264 Avg Close — Range —