ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

TOCQUEVILLE ASSET MANAGEMENT L.P.'s Holding History (CIK: 0000883961)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 1,178,628 Value ($000) $47,640 Avg Close — Range —
Q2 2015
Shares 1,226,471 Value ($000) $70,583 Avg Close — Range —
Q1 2015
Shares 1,248,614 Value ($000) $79,499 Avg Close — Range —
Q4 2014
Shares 1,466,932 Value ($000) $90,568 Avg Close — Range —
Q3 2014
Shares 1,832,109 Value ($000) $71,141 Avg Close — Range —
Q2 2014
Shares 1,862,903 Value ($000) $64,177 Avg Close — Range —
Q1 2014
Shares 1,261,703 Value ($000) $54,518 Avg Close — Range —
Q4 2013
Shares 1,659,884 Value ($000) $66,130 Avg Close — Range —
Q3 2013
Shares 1,659,559 Value ($000) $62,300 Avg Close — Range —
Q2 2013
Shares 1,941,753 Value ($000) $52,175 Avg Close — Range —