ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

CHARLES SCHWAB INVESTMENT MANAGEMENT INC's Holding History (CIK: 0000884546)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 234,831 Value ($000) $9,492 Avg Close — Range —
Q2 2015
Shares 217,885 Value ($000) $12,540 Avg Close — Range —
Q1 2015
Shares 379,530 Value ($000) $24,165 Avg Close — Range —
Q4 2014
Shares 359,236 Value ($000) $22,180 Avg Close — Range —
Q3 2014
Shares 350,159 Value ($000) $13,597 Avg Close — Range —
Q2 2014
Shares 344,459 Value ($000) $11,867 Avg Close — Range —
Q1 2014
Shares 341,177 Value ($000) $14,743 Avg Close — Range —
Q4 2013
Shares 353,862 Value ($000) $14,098 Avg Close — Range —
Q3 2013
Shares 289,041 Value ($000) $10,972 Avg Close — Range —
Q2 2013
Shares 411,600 Value ($000) $11,719 Avg Close — Range —