ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

AXA S.A.'s Holding History (CIK: 0000898427)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 323,518 Value ($000) $13,077 Avg Close — Range —
Q2 2015
Shares 249,372 Value ($000) $14,351 Avg Close — Range —
Q1 2015
Shares 249,372 Value ($000) $15,878 Avg Close — Range —
Q4 2014
Shares 187,646 Value ($000) $11,585 Avg Close — Range —
Q3 2014
Shares 175,640 Value ($000) $6,820 Avg Close — Range —
Q2 2014
Shares 176,768 Value ($000) $6,090 Avg Close — Range —
Q1 2014
Shares 183,879 Value ($000) $7,945 Avg Close — Range —
Q4 2013
Shares 174,304 Value ($000) $6,944 Avg Close — Range —
Q3 2013
Shares 165,635 Value ($000) $6,218 Avg Close — Range —
Q2 2013
Shares 130,398 Value ($000) $3,504 Avg Close — Range —