ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

WELLINGTON MANAGEMENT GROUP LLP's Holding History (CIK: 0000902219)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 424,018 Value ($000) $17,139 Avg Close — Range —
Q2 2015
Shares 513,675 Value ($000) $29,562 Avg Close — Range —
Q1 2015
Shares 1,176,083 Value ($000) $74,881 Avg Close — Range —
Q4 2014
Shares 348,501 Value ($000) $21,517 Avg Close — Range —
Q3 2014
Shares 53,249 Value ($000) $2,068 Avg Close — Range —
Q2 2014
Shares 438,879 Value ($000) $15,119 Avg Close — Range —
Q1 2014
Shares 556,434 Value ($000) $24,043 Avg Close — Range —
Q4 2013
Shares 654,759 Value ($000) $26,086 Avg Close — Range —
Q3 2013
Shares 166,800 Value ($000) $6,262 Avg Close — Range —
Q2 2013
Shares 58,400 Value ($000) $1,569 Avg Close — Range —