ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

BLAIR WILLIAM & CO/IL's Holding History (CIK: 0000902367)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 5,975 Value ($000) $343 Avg Close — Range —
Q1 2015
Shares 6,093 Value ($000) $388 Avg Close — Range —
Q4 2014
Shares 6,008 Value ($000) $370 Avg Close — Range —
Q3 2014
Shares 5,812 Value ($000) $225 Avg Close — Range —
Q1 2014
Shares 5,612 Value ($000) $242 Avg Close — Range —
Q4 2013
Shares 5,612 Value ($000) $223 Avg Close — Range —
Q3 2013
Shares 5,547 Value ($000) $208 Avg Close — Range —