ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

MASSACHUSETTS FINANCIAL SERVICES CO /MA/'s Holding History (CIK: 0000912938)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 374,503 Value ($000) $15,138 Avg Close — Range —
Q2 2015
Shares 934,782 Value ($000) $53,796,704 Avg Close — Range —
Q1 2015
Shares 974,651 Value ($000) $62,056,029 Avg Close — Range —
Q4 2014
Shares 1,097,668 Value ($000) $67,770,022 Avg Close — Range —
Q3 2014
Shares 1,034,930 Value ($000) $40,186 Avg Close — Range —
Q2 2014
Shares 563,506 Value ($000) $19,413 Avg Close — Range —
Q1 2014
Shares 462,150 Value ($000) $19,969,502 Avg Close — Range —