ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Invesco Ltd.'s Holding History (CIK: 0000914208)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 290,249 Value ($000) $11,733 Avg Close — Range —
Q2 2015
Shares 322,056 Value ($000) $18,534 Avg Close — Range —
Q1 2015
Shares 513,961 Value ($000) $32,724 Avg Close — Range —
Q4 2014
Shares 329,318 Value ($000) $20,332 Avg Close — Range —
Q3 2014
Shares 319,918 Value ($000) $12,422 Avg Close — Range —
Q2 2014
Shares 375,944 Value ($000) $12,951 Avg Close — Range —
Q1 2014
Shares 407,498 Value ($000) $17,608 Avg Close — Range —
Q4 2013
Shares 374,036 Value ($000) $14,902 Avg Close — Range —
Q3 2013
Shares 361,033 Value ($000) $13,554 Avg Close — Range —
Q2 2013
Shares 326,422 Value ($000) $8,771 Avg Close — Range —