ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM's Holding History (CIK: 0000919079)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 285,300 Value ($000) $11,532 Avg Close — Range —
Q2 2015
Shares 285,300 Value ($000) $16,419 Avg Close — Range —
Q1 2015
Shares 256,800 Value ($000) $18,592 Avg Close — Range —
Q4 2014
Shares 256,800 Value ($000) $18,592 Avg Close — Range —
Q3 2014
Shares 256,800 Value ($000) $9,972 Avg Close — Range —
Q2 2014
Shares 256,800 Value ($000) $8,847 Avg Close — Range —
Q1 2014
Shares 211,900 Value ($000) $7,770 Avg Close — Range —
Q4 2013
Shares 226,900 Value ($000) $9,296 Avg Close — Range —
Q3 2013
Shares 231,894 Value ($000) $8,705 Avg Close — Range —
Q2 2013
Shares 188,794 Value ($000) $5,073 Avg Close — Range —