ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

GLOBEFLEX CAPITAL L P's Holding History (CIK: 0000921531)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 3,300 Value ($000) $133 Avg Close — Range —
Q2 2015
Shares 11,600 Value ($000) $668 Avg Close — Range —
Q1 2015
Shares 29,700 Value ($000) $1,891 Avg Close — Range —
Q4 2014
Shares 29,800 Value ($000) $1,840 Avg Close — Range —
Q3 2014
Shares 29,823 Value ($000) $1,158 Avg Close — Range —
Q2 2014
Shares 29,919 Value ($000) $1,030 Avg Close — Range —
Q1 2014
Shares 25,600 Value ($000) $1,106 Avg Close — Range —
Q4 2013
Shares 25,700 Value ($000) $1,023 Avg Close — Range —
Q3 2013
Shares 25,700 Value ($000) $964 Avg Close — Range —
Q2 2013
Shares 25,700 Value ($000) $690 Avg Close — Range —