ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 4,102 Value ($000) $166 Avg Close — Range —
Q2 2015
Shares 4,157 Value ($000) $239 Avg Close — Range —
Q1 2015
Shares 160,441 Value ($000) $10,215 Avg Close — Range —
Q4 2014
Shares 165,473 Value ($000) $10,216 Avg Close — Range —
Q3 2014
Shares 190,298 Value ($000) $7,389 Avg Close — Range —
Q2 2014
Shares 198,712 Value ($000) $6,846 Avg Close — Range —
Q1 2014
Shares 148,179 Value ($000) $6,403 Avg Close — Range —
Q4 2013
Shares 85,055 Value ($000) $3,389 Avg Close — Range —
Q3 2013
Shares 84,652 Value ($000) $3,178 Avg Close — Range —
Q2 2013
Shares 85,967 Value ($000) $2,310 Avg Close — Range —