ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM's Holding History (CIK: 0000938076)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 152,083 Value ($000) $6,147 Avg Close — Range —
Q2 2015
Shares 150,077 Value ($000) $8,637 Avg Close — Range —
Q1 2015
Shares 91,009 Value ($000) $5,795 Avg Close — Range —
Q4 2014
Shares 97,377 Value ($000) $6,012 Avg Close — Range —
Q3 2014
Shares 101,345 Value ($000) $3,935 Avg Close — Range —
Q2 2014
Shares 103,185 Value ($000) $3,555 Avg Close — Range —
Q1 2014
Shares 101,556 Value ($000) $4,388 Avg Close — Range —
Q4 2013
Shares 103,716 Value ($000) $4,132 Avg Close — Range —
Q3 2013
Shares 104,726 Value ($000) $3,931 Avg Close — Range —
Q2 2013
Shares 104,726 Value ($000) $2,814 Avg Close — Range —