ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

DEUTSCHE BANK AG\'s Holding History (CIK: 0000948046)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 1,323,445 Value ($000) $53,491 Avg Close — Range —
Q2 2015
Shares 1,062,757 Value ($000) $61,158 Avg Close — Range —
Q1 2015
Shares 1,007,482 Value ($000) $64,142 Avg Close — Range —
Q4 2014
Shares 928,678 Value ($000) $57,334 Avg Close — Range —
Q3 2014
Shares 546,232 Value ($000) $21,207 Avg Close — Range —
Q2 2014
Shares 682,894 Value ($000) $23,523 Avg Close — Range —
Q1 2014
Shares 376,102 Value ($000) $16,250 Avg Close — Range —
Q4 2013
Shares 356,722 Value ($000) $14,209 Avg Close — Range —
Q3 2013
Shares 731,443 Value ($000) $27,456 Avg Close — Range —