ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 13,823 Value ($000) $559 Avg Close — Range —
Q2 2015
Shares 48,569 Value ($000) $2,795 Avg Close — Range —
Q1 2015
Shares 36,077 Value ($000) $2,297 Avg Close — Range —
Q4 2014
Shares 37,825 Value ($000) $2,335 Avg Close — Range —
Q3 2014
Shares 42,525 Value ($000) $1,651 Avg Close — Range —
Q2 2014
Shares 27,028 Value ($000) $931 Avg Close — Range —
Q2 2013
Shares 25,227 Value ($000) $678 Avg Close — Range —