ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

FRANKLIN STREET ADVISORS INC /NC's Holding History (CIK: 0001010873)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 18,612 Value ($000) $753 Avg Close — Range —
Q2 2015
Shares 18,612 Value ($000) $1,071 Avg Close — Range —
Q1 2015
Shares 18,612 Value ($000) $1,185 Avg Close — Range —
Q4 2014
Shares 23,612 Value ($000) $1,458 Avg Close — Range —
Q3 2014
Shares 23,612 Value ($000) $917 Avg Close — Range —
Q2 2014
Shares 23,612 Value ($000) $813 Avg Close — Range —
Q1 2014
Shares 23,612 Value ($000) $1,021 Avg Close — Range —
Q4 2013
Shares 23,612 Value ($000) $940 Avg Close — Range —
Q3 2013
Shares 23,612 Value ($000) $886 Avg Close — Range —
Q2 2013
Shares 45,112 Value ($000) $1,212 Avg Close — Range —