ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

HBK INVESTMENTS L P's Holding History (CIK: 0001011443)

Note: Option positions (PUT/CALL) are excluded.

Q1 2014
Shares 42,600 Value ($000) $1,841 Avg Close — Range —
Q3 2013
Shares 26,799 Value ($000) $1,006 Avg Close — Range —