ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

EMERALD ADVISERS, LLC's Holding History (CIK: 0001015083)

Note: Option positions (PUT/CALL) are excluded.

Q1 2015
Shares 5,337 Value ($000) $321 Avg Close — Range —
Q4 2014
Shares 171,069 Value ($000) $10,562 Avg Close — Range —
Q3 2014
Shares 246,754 Value ($000) $9,581 Avg Close — Range —
Q2 2014
Shares 198,934 Value ($000) $6,853 Avg Close — Range —
Q1 2014
Shares 176,436 Value ($000) $7,624 Avg Close — Range —
Q4 2013
Shares 322,333 Value ($000) $12,842 Avg Close — Range —
Q3 2013
Shares 305,945 Value ($000) $11,485 Avg Close — Range —
Q2 2013
Shares 272,927 Value ($000) $7,334 Avg Close — Range —