ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

NATIXIS ADVISORS, L.P.'s Holding History (CIK: 0001018331)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 45,975 Value ($000) $1,858 Avg Close — Range —
Q2 2015
Shares 43,880 Value ($000) $2,525 Avg Close — Range —
Q1 2015
Shares 43,227 Value ($000) $2,752 Avg Close — Range —
Q4 2014
Shares 44,731 Value ($000) $2,762 Avg Close — Range —
Q3 2014
Shares 40,551 Value ($000) $1,575 Avg Close — Range —
Q2 2014
Shares 35,107 Value ($000) $1,209 Avg Close — Range —
Q1 2014
Shares 30,123 Value ($000) $1,302 Avg Close — Range —
Q4 2013
Shares 32,971 Value ($000) $1,314 Avg Close — Range —
Q3 2013
Shares 34,446 Value ($000) $1,293 Avg Close — Range —
Q2 2013
Shares 42,646 Value ($000) $1,146 Avg Close — Range —