ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Smithfield Trust Co's Holding History (CIK: 0001019754)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 2,110 Value ($000) $121 Avg Close — Range —
Q1 2015
Shares 2,180 Value ($000) $139 Avg Close — Range —