ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Granahan Investment Management, LLC's Holding History (CIK: 0001026710)

Note: Option positions (PUT/CALL) are excluded.

Q3 2013
Shares 842,689 Value ($000) $31,635 Avg Close — Range —
Q2 2013
Shares 911,189 Value ($000) $24,484 Avg Close — Range —