ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

PARADIGM ASSET MANAGEMENT CO LLC's Holding History (CIK: 0001034549)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 74,500 Value ($000) $3,011,290 Avg Close — Range —
Q4 2014
Shares 69,050 Value ($000) $4,263,147 Avg Close — Range —
Q3 2014
Shares 97,450 Value ($000) $3,783,984 Avg Close — Range —
Q2 2014
Shares 15,850 Value ($000) $546,033 Avg Close — Range —
Q1 2014
Shares 29,550 Value ($000) $1,276,856 Avg Close — Range —
Q4 2013
Shares 31,850 Value ($000) $1,268,904 Avg Close — Range —
Q3 2013
Shares 32,650 Value ($000) $1,225,681 Avg Close — Range —
Q2 2013
Shares 34,150 Value ($000) $917,610 Avg Close — Range —