ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

GREAT WEST LIFE ASSURANCE CO /CAN/'s Holding History (CIK: 0001046192)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 22,713 Value ($000) $919 Avg Close — Range —
Q2 2015
Shares 18,583 Value ($000) $1,068 Avg Close — Range —
Q1 2015
Shares 18,583 Value ($000) $1,182 Avg Close — Range —
Q4 2014
Shares 10,308 Value ($000) $635 Avg Close — Range —
Q3 2014
Shares 10,308 Value ($000) $402 Avg Close — Range —
Q2 2014
Shares 8,217 Value ($000) $282 Avg Close — Range —
Q1 2014
Shares 8,217 Value ($000) $353 Avg Close — Range —
Q4 2013
Shares 8,217 Value ($000) $329 Avg Close — Range —