ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Artal Group S.A.'s Holding History (CIK: 0001053906)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 400,000 Value ($000) $16,168 Avg Close — Range —
Q2 2015
Shares 400,000 Value ($000) $23,020 Avg Close — Range —
Q1 2015
Shares 400,000 Value ($000) $25,468 Avg Close — Range —
Q4 2014
Shares 405,000 Value ($000) $25,005 Avg Close — Range —
Q3 2014
Shares 455,000 Value ($000) $17,668 Avg Close — Range —
Q2 2014
Shares 455,000 Value ($000) $15,675 Avg Close — Range —
Q1 2014
Shares 100,000 Value ($000) $4,321 Avg Close — Range —