ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

PUZO MICHAEL J's Holding History (CIK: 0001053914)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 13,450 Value ($000) $544 Avg Close — Range —
Q2 2015
Shares 13,450 Value ($000) $774 Avg Close — Range —
Q1 2015
Shares 14,250 Value ($000) $907 Avg Close — Range —
Q4 2014
Shares 12,800 Value ($000) $790 Avg Close — Range —
Q3 2014
Shares 11,100 Value ($000) $431 Avg Close — Range —
Q2 2014
Shares 7,540 Value ($000) $260 Avg Close — Range —