ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

NOMURA ASSET MANAGEMENT CO LTD's Holding History (CIK: 0001055964)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 12,220 Value ($000) $494 Avg Close — Range —
Q2 2015
Shares 21,220 Value ($000) $1,221 Avg Close — Range —
Q1 2015
Shares 26,220 Value ($000) $1,669 Avg Close — Range —
Q4 2014
Shares 17,500 Value ($000) $1,080 Avg Close — Range —
Q3 2014
Shares 17,500 Value ($000) $680 Avg Close — Range —
Q2 2014
Shares 15,000 Value ($000) $517 Avg Close — Range —
Q1 2014
Shares 15,000 Value ($000) $648 Avg Close — Range —
Q4 2013
Shares 15,000 Value ($000) $598 Avg Close — Range —
Q3 2013
Shares 20,000 Value ($000) $751 Avg Close — Range —
Q2 2013
Shares 25,000 Value ($000) $672 Avg Close — Range —