ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

FEDERATED HERMES, INC.'s Holding History (CIK: 0001056288)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 67,527 Value ($000) $2,729 Avg Close — Range —
Q2 2015
Shares 54,042 Value ($000) $3,110 Avg Close — Range —
Q1 2015
Shares 37,439 Value ($000) $2,384 Avg Close — Range —
Q4 2014
Shares 24,666 Value ($000) $1,523 Avg Close — Range —
Q3 2014
Shares 20,308 Value ($000) $789 Avg Close — Range —
Q2 2014
Shares 14,452 Value ($000) $498 Avg Close — Range —
Q1 2014
Shares 30,824 Value ($000) $1,332 Avg Close — Range —
Q4 2013
Shares 22,467 Value ($000) $895 Avg Close — Range —
Q3 2013
Shares 22,847 Value ($000) $858 Avg Close — Range —
Q2 2013
Shares 15,788 Value ($000) $424 Avg Close — Range —