ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Asset Management One Co., Ltd.'s Holding History (CIK: 0001068855)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 10,990 Value ($000) $421 Avg Close — Range —
Q2 2015
Shares 11,640 Value ($000) $655 Avg Close — Range —
Q1 2015
Shares 11,640 Value ($000) $751 Avg Close — Range —