ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM's Holding History (CIK: 0001081019)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 218,340 Value ($000) $8,825 Avg Close — Range —
Q2 2015
Shares 218,640 Value ($000) $12,583 Avg Close — Range —
Q1 2015
Shares 215,381 Value ($000) $13,713 Avg Close — Range —
Q4 2014
Shares 219,181 Value ($000) $13,532 Avg Close — Range —
Q3 2014
Shares 217,053 Value ($000) $8,428 Avg Close — Range —
Q2 2014
Shares 214,621 Value ($000) $7,394 Avg Close — Range —
Q1 2014
Shares 204,321 Value ($000) $8,829 Avg Close — Range —
Q4 2013
Shares 203,321 Value ($000) $8,100 Avg Close — Range —
Q3 2013
Shares 202,021 Value ($000) $7,584 Avg Close — Range —
Q2 2013
Shares 195,714 Value ($000) $5,259 Avg Close — Range —
Q1 2013
Shares 174,165 Value ($000) $2,950 Avg Close — Range —