ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

KEYBANK NATIONAL ASSOCIATION/OH's Holding History (CIK: 0001089877)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 5,358 Value ($000) $217 Avg Close — Range —
Q2 2015
Shares 11,993 Value ($000) $690 Avg Close — Range —
Q1 2015
Shares 15,091 Value ($000) $961 Avg Close — Range —
Q4 2014
Shares 9,334 Value ($000) $576 Avg Close — Range —
Q3 2014
Shares 20,477 Value ($000) $795 Avg Close — Range —
Q2 2014
Shares 29,443 Value ($000) $1,014 Avg Close — Range —
Q1 2014
Shares 30,288 Value ($000) $1,309 Avg Close — Range —