ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

ADVENT CAPITAL MANAGEMENT /DE/'s Holding History (CIK: 0001097278)

Note: Option positions (PUT/CALL) are excluded.

Q4 2013
Shares 11,604 Value ($000) $462 Avg Close — Range —
Q2 2013
Shares 14,500 Value ($000) $390 Avg Close — Range —