ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Paloma Partners Management Co's Holding History (CIK: 0001103882)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 6,808 Value ($000) $275 Avg Close — Range —
Q2 2015
Shares 150,206 Value ($000) $8,646 Avg Close — Range —
Q1 2015
Shares 13,160 Value ($000) $838 Avg Close — Range —
Q4 2014
Shares 3,326 Value ($000) $205 Avg Close — Range —
Q2 2014
Shares 75,000 Value ($000) $2,584 Avg Close — Range —
Q1 2014
Shares 70,079 Value ($000) $3,028 Avg Close — Range —
Q4 2013
Shares 50,000 Value ($000) $1,992 Avg Close — Range —
Q3 2013
Shares 31,500 Value ($000) $1,183 Avg Close — Range —
Q2 2013
Shares 31,734 Value ($000) $853 Avg Close — Range —