ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

CASTLEARK MANAGEMENT LLC's Holding History (CIK: 0001106832)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 29,625 Value ($000) $1,705 Avg Close — Range —
Q1 2015
Shares 147,663 Value ($000) $9,402 Avg Close — Range —
Q4 2014
Shares 165,888 Value ($000) $10,242 Avg Close — Range —
Q3 2013
Shares 108,500 Value ($000) $4,213 Avg Close — Range —