ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

ALLIANCEBERNSTEIN L.P.'s Holding History (CIK: 0001109448)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 959,952 Value ($000) $38,801 Avg Close — Range —
Q2 2015
Shares 797,958 Value ($000) $45,922 Avg Close — Range —
Q1 2015
Shares 1,050,658 Value ($000) $66,895 Avg Close — Range —
Q4 2014
Shares 914,542 Value ($000) $56,464 Avg Close — Range —
Q3 2014
Shares 969,767 Value ($000) $37,656 Avg Close — Range —
Q2 2014
Shares 1,107,527 Value ($000) $38,154 Avg Close — Range —
Q1 2014
Shares 1,140,853 Value ($000) $49,296 Avg Close — Range —
Q4 2013
Shares 1,115,777 Value ($000) $44,453 Avg Close — Range —
Q3 2013
Shares 1,472,554 Value ($000) $55,280 Avg Close — Range —
Q2 2013
Shares 1,446,363 Value ($000) $38,864 Avg Close — Range —